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선천성 콜라겐 결핍증의 증상은 환자마다 다르게 나타난다. 일반적으로 나타나는 증상으로는 피부의 비정상적인 탄력성, 쉽게 멍이 드는 경향, 관절의 과도한 유연성, 그리고 뼈의 약화 등이 있다.
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